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February 22, 2012 by snowflake
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As an embryo develops, different genes are turned on in different cells, to form muscles, neurons and other bodily parts. Inside each cell's nucleus, genetic sequences known as enhancers act like remote controls, switching genes on and off. Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, can now see -- and predict -- exactly when each remote control is itself activated, in a real embryo. Their work was recently published in Nature Genetics.
Stefan Bonn, Robert Zinzen and Charles Girardot, all in Eileen Furlong's lab at EMBL, found that specific combinations of chromatin modifications -- chemical tags that promote or hinder gene expression -- are placed at and removed from enhancers at precise times during development, switching those remote controls on or off.
"Our new method provides cell-type specific information on the activity status of an enhancer and of a gene, within a developing multicellular embryo," says Furlong.
The scientists looked at known enhancers, and compared those that were active to those that were inactive in a type of cells called mesoderm at a particular time in fruit fly development. They noted what chromatin modifications each of those enhancers had, and trained a computer model to accurately predict if an enhancer is active or inactive, based solely on what chromatin marks it bears.
In future, the scientists plan to use this method to study the interplay between the activity status of an enhancer and the presence of key switches, termed transcription factors, at different stages of embryonic development, and in different tissue types, generating an ever more complete picture of how a single cell grows into a complex organism.http:/
February 3, 2012 by snowflake
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Redneck sex quiz
Study each question carefully. Then, choose the answer that seems most correct (True or False) and circle the T or F as appropriate.
1. A clitoris is a type of flower. T F
2. Pubic hair is a wild rabbit. T F
3. "Spread Eagle" is an extinct bird. T F
4. Vagina is a medical term used to describe heart trouble. T F
5. Menstrual cycle has three (3) wheels. T F
6. A G-string is part of a violin. T F
7. Semen is another word for "sailor". T F
8. Anus is the Latin word for "yearly". T F
9. Testicles are found on an octopus. T F
10. Asphalt describes rectal troubles. T F
11. Masturbate is used to catch large fish. T F
12. KOTEX is a radio station in Bryan, Texas. T F
13. Coitus is a musical instrument. T F
14. Fetus is a character on "Gunsmoke". T F
15. An umbilical cord is part of a parachute. T F
16. A condom is an apartment complex. T F
17. An organism is the person who accompanies the chior in church. T F
18. A diaphram is a drawing in geometry. T F
19. A dildo is a variety of sweet pickle. T F
20. An erection is when the Japanese vote for their new government officials. T F
21. A lesbian is a person from the Middle East. T F
22. Sodomy is a special kind of fast-growing grass. T F
23. Pornography is the business of making record albums. T F
24. Genitals are people of non-Jewish origins. T F
25. Douche is the Italian word for "twelve". T F
26. An enema is someone who is not your friend. T F
27. Ovaries are a French egg dish made with cheese. T F
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January 4, 2012 by snowflake
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How did I come into this world?
Daddy? How did I come into this world?"
"Well, my child, someday I'll have to tell you anyway."
"So why not today? Please!"
"OK, but listen carefully."
"Mom and Dad met each other in a cybercafe. In the restrooms of that cybercafe, dad connected to mom. Mom at that time made some downloads from dad's memorystick. When dad finished up loading wed is covered we used no firewall. Since it was too late to cancel or delete, nine months later we ended up with a virus."
He was only wrong by two
Jack Hawkins was the football coach at an Amercian college, and he was always trying to find good players, but they weren't always smart enought to be accepted by the college.
One day the coach brought an excellent young player to the dean of the college and asked that the student be allowed to enter without an examination. "Well," the dean said after some persuasion, "I'd better ask him a few questions first."
Then he turned to the student and asked him some very easy questions, but the student didn't know any of the answers.
At last the dean said, "Well, what's five times seven?"
The student thought for a long time and then answered, "Thirty-six."
The dean threw up his hands and looked at the coach in despair, but the coach said earnestly , "Oh, please let him in, sir! He was only wrong by two."
S.O.B.
My father, who was 14 years old than my mother, had been working on his will. At a family dinner he told us that he had provided well for Mother, but the family home would go to us five children if she remarried.
"I don't want another S.O.B. toasting his shins around my fireplace," he explained.
With a sly grin, Mother cracked, "What makes you think I'd marry another S.O.B?"
Present for Girlfriend
At a jewelry store, a young man bought an expensive locket as a present for his girlfriend. "Shall I engrave her name on it?" the jeweler asked.
The customer thought for a moment, and then said, "No-engrave it 'To my one and only love'. That way, if we ever break up, I can use it again."http:/
December 20, 2011 by snowflake
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Christmas is coming and every year despite the fact that we promise to ourselves to buy all our presents in time, we are always caught up in so many things that December is at our door and still our Christmas list is virtually empty.Luckily the internet and online shopping is here to help everyone in choosing and buying presents for loved ones.
Shopping online is very safe especially if websites are all their certificates about security and safe credit cards inputs. infinityjewellery.com is the natural choice for a visit, a browse and to find the perfect gift in a range of high quality jewellery, diamonds certified by the main gemmological institutes in the world and a service second to none.Christmas is the perfect time to make a commitment, to celebrate an important stage in life, something to be remembered with a gift that lasts forever.
Infinity Jewellery has got a collection to suit all the budgets and now many items are on sale just for a limited period of time with great savings on its 18ct gold diamonds jewellery.
Infinity Jewellery has got its workshops in the jewellery quarter in London, Hatton Garden, home to the goldsmith craft for centuries, since the medieval times and all its piece of jewellery come with the London Assay Office Hallmark which guarantee the quality of the metal used.
Apart from the ready made items, Infinity Jewellery offers a bespoke service in order to realize your design or to choose among different qualities of diamonds and mounts and have in this way a tailored piece of jewellery with its own meaning. For example would not be lovely to give for a 40th birthday a pendant or a ring with a 40 points diamond to mark the event? With Infinity Jewellery, this is just one of the several ideas coming out from the designer's mind to make a jewellery purchase something unique and personal.
Placing an order now will guarantee to have the delivery in time for Christmas and it is so easy to make a payment with the website accepting all the major credit cards and Paypal which is becoming more popular than ever and very safe. Infinity Jewellery will give peace of mind, quality and the certainty that your Christmas present will be a success.Infinity-Jewellery.com provide you good quality of diamond rings, Diamond Trilogy Ring, Diamond Rings London and Trilogy Rings, Emerald Cluster Ring while shopping. Find details in our informative website to learn more about Engagement Rings London and jewellery collection. http:/
December 15, 2011 by snowflake
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The home your provide for your children should be one of the safest places for them to be but shocking statistics show that an average 2,096 children under the age of 14 die each year in the US from a home injury as reported by the US Home Safety Council. So how can we make our homes a safer environment for our children?Baby-Proofing Your Child's RoomWhen we buy furniture and accessories for our children's rooms we often choose them on looks first, then quality with safety coming low on our list of priorities however safety should be top of our list.• All bedding and mattresses should meet current fire standards regulations and this should be clearly marked on the label.• Ideally corners should be rounded to prevent nasty cuts and bashes but if they are not then you can buy corner guards that simply attach to those sharp corners making them much more child-friendly.• Check that drawers are fitted with safety mechanisms to prevent little fingers from getting trapped.• Windows should be fitted with window guards to stop them from being opened too wide and window dressings such as cords should be kept safely out of the way of little hands. Similarly don't hang anything within reach of their cots, including mobiles.• All electrical cords should also be kept out of reach and wall sockets blocked.• Furniture should be secure and drawers and bookshelves fastened to the wall. Make sure that there is nothing they cannot reach without having to stand on something.Have a crawl around their room on your hands and knees. It might look silly but only at this perspective can you get access to the areas they are most likely to explore and spot any potential hazards.Preventing FallsWhen a toddler starts to explore their environment, this is when they are most vulnerable to falls and trips as they are unsteady on their feet and just finding their balance. Hard as it might be, try to keep rooms free from clutter. Simple storage are very effective at providing specific areas for toys and other household clutter, thus keeping them off the floor.Also ensure that stair gates are fitted to both the top and bottom of any staircases and that stairs are kept clear and the carpets are not worn or damaged.Hard floors are not ideal for children as they can get slippy, especially when wearing socks; spillages become hazardous and of course a hard floor is not a nice thing to land on. So consider carpeting the rooms your child uses most, like the living room and bedroom and check that any rugs on hard floors have a non-slip lining.First AidYou cannot prevent 100% of accidents in your home but you can significantly reduce the risk by taking some simple precautions. Above all, consider signing yourself up for a First Aid Course which will give you the confidence and knowledge to be able to deal with any kind of trauma, from a bruised knee to something more serious such as choking. Because, no matter how careful you are as a parent, accidents still do happen but you can make a huge difference to the outcome with a little bit of training. http:/





